Effective January 1, 2018, University Ministry and the Office of Mission and Values came together to form a new division: the Division of Mission and Ministry.

Mission and Ministry focuses its activities on serving the spiritual needs of the DePaul University students, their Vincentian service to the poor and vulnerable, and their exploration of social justice. Mission and Ministry also collaborates with university units to maximize faculty and staff engagement with the university's mission and values, and to enhance their understanding and support of DePaul University's distinctive Catholic, Vincentian, and urban identity.

The division was first led by the Rev. Edward Udovic, C.M., vice president for Mission and Ministry, and now vice president emeritus, retired.