Date of Award
Master of Science (MS)
The Pictet-Spengler reaction rates of three species known to exhibit the alpha effect will be compared to the rate of the amine functional group. This is part of a larger effort to to generate a bifunctional tool for protein ligation by attaching an alkyne or azide group to the amine. With this, the aldehyde tag method can be used to modify proteins in biological conditions cheaply, specifically, and efficiently.
Williams, Jermell, "Anthraquinone Extraction and Quantification, Modification of the Pictet-Spengler Reaction for the Creation of Useful Isotopes and Use in Protein Ligation" (2021). College of Science and Health Theses and Dissertations. 392.