Faculty Advisor
Kyle A. Grice
Abstract
The search for sustainability in chemistry has led to the development of the field of Green Chemistry, comprised by 12 guiding principles. Existing syntheses of benzimidazoles, a heterocycle widely used in medicinal chemistry, utilize methods with much room for improved sustainability. This work presents a solventless mechanochemical synthesis of 1,2-disubsituted substituted benzimidazoles from the condensation of phenylenediamines and aryl aldehydes. The effect of milling aid on yield and selectivity was investigated and montmorillonite K10 was determined to be the best milling aid. The purification protocol was optimized as well, with a heptane:EtOAc extraction and subsequent recrystallization from EtOH found to give the purest product in highest yield.
Recommended Citation
Jaffery, Zachary A.; Christopher, Katherine E.; and Grice, Kyle A.
(2026)
"Solvent-Free Ball-Milling Synthesis of 1,2-disubstituted benzimidazoles,"
DePaul Discoveries: Volume 15, Article 10.
Available at:
https://via.library.depaul.edu/depaul-disc/vol15/iss1/10