Caitlin E. Karver
Caspase-1 is an enzyme that is overactive in autoimmune and autoinflammatory diseases cleaving pro-interleukin-1β to the cytokine interleukin-1β (IL-1β), which leads to inflammatory symptoms. The inhibition of caspase-1 will cause a decrease in the concentration of interleukin-1β (IL-1β), resulting in the reduction of inflammatory symptoms. Recent research has revealed that the appending of a nitric oxide (NO) or nitroxyl (HNO) donating group to non-steroidal anti-inflammatory drugs (NSAIDs) reduced, or avoided, the side effects caused by currently available treatments. A small molecule based on a known caspase-1 inhibitor with a nitrosocysteine appended on was synthesized to look at the effect of NO donation on caspase-1.
Shamblen, Catherine A. and Karver, Caitlin E.
"Synthesis of a Small Molecule Nitrosocysteine Inhibitor to Reduce the Activity of Caspase-1,"
DePaul Discoveries: Vol. 5
, Article 5.
Available at: http://via.library.depaul.edu/depaul-disc/vol5/iss1/5