Title

Utilizing the PDB and HSAB Theory to Understand Metal Specificity in Trafficking Proteins

Document Type

Article

Publication Date

7-17-2014

Comments

This is an in-class PDB exercise based on the paper "Mechanisms Controlling the Cellular Metal Economy" by Gilston and O'Halloran. Students are asked to visualize the metal binding sites of several proteins discussed in the paper, highlighting unusual metal geometries. After identifying the amino acid residues involved in metal binding, students will discuss the bond structure in terms of HSAB theory.

Embargo

2019

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