Faculty Publications – College of Science and Health


Structural comparison of suberanilohydroxamic acid (SAHA) and other zinc-enzyme inhibitors bound to a monomeric zinc species

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Histone Deacetylase (HDAC) and similar proteins contain an active Zn–OH group and have been targets for inhibitors. Known inhibitors such as suberanilohydroxamic acid (SAHA), suberohydroxamic acid (SBHA), valproic acid, and 8-hydroxyquinoline (8-HQ) derivatives act on these enzymes by binding to the zinc center. To examine how these drugs interacted with zinc centers and to examine their structural differences, a homogeneous zinc complex was synthesized and reacted with SAHA, SBHA, valproic acid, and 8-HQ to form stable adducts, which were characterized by spectroscopy and X-ray crystallography. A comparison of their structures with known complexes and enzyme active sites bound to drugs was performed in order to understand how these drugs interact with their targets.