Charles M. Rubert Pérez
Intermolecular forces, such as H-bonding, ionic interactions and metal chelation between small molecules, can lead to the assembly of higher-order supramolecular nanostructures. A metal chelator, 2-(Pyridin-2-yl) pyridine-5-carboxylic Acid (a bipyridine derivative), is expected to aid in the formation of supramolecular structures as part of amphiphilic molecules that self-assemble in solution in the presence of metal ions. The bipyridine ligand currently under synthesis can be prepared through a five-step synthesis scheme. The second reaction of this synthesis (the coupling of two pyridine rings) resulted in a combination of the desired 1,2,5-isomer, as well as an unforeseen 1,2,3-isomer. Future research will therefore examine how this reaction can be improved, or circumnavigated altogether, so as to maximize the yield of the 1,2,5-configuration. Once properly synthesized, the bipyridine will be incorporated into an amphiphilic scaffold and assessed for its ability to form supramolecular polymers in the presence of various divalent metal cations.
Gould, Andrew D.
"Synthesis of a Bipyridine Ligand for Metal-Triggered Supramolecular Polymers,"
DePaul Discoveries: Vol. 7
, Article 6.
Available at: http://via.library.depaul.edu/depaul-disc/vol7/iss1/6