Approximately 170 million people are infected with Hepatitis C virus (HCV) worldwide5,6. It is estimated that roughly 80% of those infected suffer from persistent infection with the virus; this persistence of infection is progressive, and over time can lead to fibrosis, cirrhosis, and hepatocellular carcinoma7. Chronic inflammation and apoptotic deregulation are both hallmarks of chronic HCV infection, and many molecular pathways are initiated in both the innate and adaptive immune responses during infection with this viral pathogen. The aim of this review was to survey some of the major molecular mechanisms responsible for the induction of chronic inflammation that occurs during HCV infection.
Lane, Samantha L.
"Chronic Inflammation as a Result of Hepatitis C Virus Infection: A Review of the Literature,"
DePaul Discoveries: Vol. 4
, Article 6.
Available at: http://via.library.depaul.edu/depaul-disc/vol4/iss1/6